Biomarker Reference · As
Arsenic (Urine, Total and Speciated) (As) is a clinical biomarker used in heavy-metals-toxicology assessment. Arsenic exists in organic (arsenobetaine, arsenocholine from seafood) and inorganic forms. It is measured in 2 laboratory tests on BiomarkersLabs.com.
Arsenic exists in organic (arsenobetaine, arsenocholine from seafood) and inorganic forms. Inorganic arsenic and its methylated metabolites (monomethylarsonic acid, dimethylarsinic acid) are toxic; arsenobetaine is non-toxic and rapidly excreted. Speciated analysis separates toxic from non-toxic forms. Urinary excretion is the primary route, with a half-life of days for inorganic arsenic.
Total urinary arsenic can be elevated after seafood consumption without toxicity; speciation is essential to identify inorganic arsenic exposure from contaminated groundwater, occupational sources (smelting, pesticides, wood preservatives), or folk remedies. Chronic inorganic arsenic toxicity causes skin lesions, peripheral neuropathy, and increased risk of bladder, lung, and skin cancers. This panel should include speciation or be interpreted with dietary history.
Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.
2 tests on BiomarkersLabs.com include this biomarker.
Arsenic (Urine, Total and Speciated) reference range in this test: Total <50 µg/g creatinine; inorganic arsenic plus metabolites <10 µg/g creatinine
Arsenic (Urine, Total and Speciated) reference range in this test: Reported against reference intervals; speciation distinguishes toxic inorganic from non-toxic organic forms # REVIEWER FLAG: Confirm whether Doctor's Data speciates arsenic on this panel — speciation is essential for interpretation.
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