What is the reference range for Allotetrahydrocortisol?

The standard reference range for Allotetrahydrocortisol is Laboratory-specific; typically 600–2000 µg/24 h.. Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

Which tests measure Allotetrahydrocortisol?

Allotetrahydrocortisol is measured in 1 test on BiomarkersLabs.com, including Adrenal Corticoids Profile.

Biomarker Reference · allo-THF

What does the Allotetrahydrocortisol test measure?

Allotetrahydrocortisol (allo-THF) is a clinical biomarker used in adrenal-stress assessment. Allotetrahydrocortisol is the 5β-reduced metabolite of cortisol, formed in the liver and excreted conjugated in urine. It is measured in 1 laboratory test on BiomarkersLabs.com.

Reference Range: Laboratory-specific; typically 600–2000 µg/24 h.
Units: µg/24 h, nmol/24 h
Measured In: 1 test
Category: Adrenal

Functional medicine optimalLaboratory-derived intervals; no consensus functional range.

What is Allotetrahydrocortisol?

Allotetrahydrocortisol is the 5β-reduced metabolite of cortisol, formed in the liver and excreted conjugated in urine. It accounts for a smaller proportion of cortisol metabolism than THF but contributes to the overall steroid metabolome. The ratio of THF to allo-THF reflects the balance of 5α- versus 5β-reductase activity.

Why is Allotetrahydrocortisol measured?

Allo-THF is measured in comprehensive urinary steroid profiles to characterise cortisol metabolism and hepatic enzyme function. Shifts in the THF-to-allo-THF ratio can indicate changes in reductase activity associated with obesity, metabolic syndrome, or enzyme-inducing medications, though clinical decision algorithms based on these ratios remain limited to specialised endocrine centres.

Reference ranges

Standard reference: Laboratory-specific; typically 600–2000 µg/24 h.
Functional medicine optimal: Laboratory-derived intervals; no consensus functional range.
Units: µg/24 h, nmol/24 h

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure Allotetrahydrocortisol

1 test on BiomarkersLabs.com include this biomarker.

BML-ADR-020Comprehensive

Adrenal Corticoids Profile

Allotetrahydrocortisol reference range in this test: Laboratory-specific; typically 600–2000 µg/24 h.

Related clinical conditions

Related Biomarkers

Frequently measured alongside

Free CortisolF1 test CortisoneE3 tests TetrahydrocortisolTHF1 test TetrahydrocortisoneTHE1 test Urinary Free Cortisol-to-Cortisone RatioF/E2 tests THF + allo-THF to THE Ratio(THF+allo-THF)/THE1 test

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