What is the reference range for Cortisone?

The standard reference range for Cortisone is Dried urine: proprietary diurnal intervals for morning, afternoon, evening, and night fractions.. Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

Biomarker Reference · E

What does the Cortisone test measure?

Q: Which tests measure Cortisone?

Cortisone is measured in 3 tests on BiomarkersLabs.com, including Adrenal Corticoids Profile, Blood Spot Thyroids + Dried Urine GCMS Estrogen Hormone Metabolites and LCMS Diurnal Hormones I, Dried Urine LCMS Neurotransmitters and Diurnal Hormones II.

Cortisone (E) is a clinical biomarker used in adrenal-stress assessment. Cortisone is the inactive 11-keto metabolite of cortisol, generated by 11β-hydroxysteroid dehydrogenase type 2 in the kidney and other tissues. It is measured in 3 laboratory tests on BiomarkersLabs.com.

Reference Range: Dried urine: proprietary diurnal intervals for morning, afternoon, evening, and night fractions.
Units: µg/24 h, nmol/24 h, ng/mg creatinine
Measured In: 3 tests
Category: Adrenal

Functional medicine optimalParallel diurnal decline with cortisol. The ratio is more informative than absolute cortisone concentration.

What is Cortisone?

Cortisone is the inactive 11-keto metabolite of cortisol, generated by 11β-hydroxysteroid dehydrogenase type 2 in the kidney and other tissues. It is rapidly interconverted with cortisol, and urinary cortisone excretion reflects both direct secretion and peripheral inactivation of cortisol. The cortisol-to-cortisone ratio provides insight into the balance between active glucocorticoid and its inactivation.

Why is Cortisone measured?

Cortisone measurement complements free cortisol in assessing adrenal glucocorticoid output and peripheral metabolism. Altered cortisol-to-cortisone ratios can signal abnormal 11β-HSD enzyme activity, seen in conditions such as apparent mineralocorticoid excess or chronic stress states, though these interpretations remain largely within the functional-medicine domain.

Reference ranges

Standard reference: Dried urine: proprietary diurnal intervals for morning, afternoon, evening, and night fractions.
Functional medicine optimal: Parallel diurnal decline with cortisol. The ratio is more informative than absolute cortisone concentration.
Units: µg/24 h, nmol/24 h, ng/mg creatinine

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure Cortisone

3 tests on BiomarkersLabs.com include this biomarker.

BML-ADR-020Comprehensive

Adrenal Corticoids Profile

Cortisone reference range in this test: Laboratory-specific; often 10–50 µg/24 h.

BML-THY-031Comprehensive

Blood Spot Thyroids + Dried Urine GCMS Estrogen Hormone Metabolites and LCMS Diurnal Hormones I

Cortisone reference range in this test: Dried urine: proprietary diurnal intervals for morning, afternoon, evening, and night fractions.

BML-NMH-008Comprehensive

Dried Urine LCMS Neurotransmitters and Diurnal Hormones II

Cortisone reference range in this test: Time-dependent; morning void typically 40–150 ng/mg, evening void 20–70 ng/mg creatinine.

Related clinical conditions

Related Biomarkers

Frequently measured alongside

Urinary Free Cortisol-to-Cortisone RatioF/E2 tests Cortisol3 tests DehydroepiandrosteroneDHEA4 tests Free CortisolF1 test TetrahydrocortisolTHF1 test Allotetrahydrocortisolallo-THF1 test TetrahydrocortisoneTHE1 test THF + allo-THF to THE Ratio(THF+allo-THF)/THE1 test

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