Biomarker Reference · F/E
Urinary Free Cortisol-to-Cortisone Ratio (F/E) is a clinical biomarker used in adrenal-stress assessment. The urinary free cortisol-to-cortisone ratio reflects the balance between active glucocorticoid and its inactivation by 11β-hydroxysteroid dehydrogenase type 2 in the kidney. It is measured in 2 laboratory tests on BiomarkersLabs.com.
The urinary free cortisol-to-cortisone ratio reflects the balance between active glucocorticoid and its inactivation by 11β-hydroxysteroid dehydrogenase type 2 in the kidney. A high ratio suggests impaired cortisol inactivation, allowing excessive mineralocorticoid receptor activation; a low ratio may indicate upregulated inactivation or reduced cortisol output.
The F/E ratio is used to investigate disorders of cortisol metabolism, including apparent mineralocorticoid excess (high ratio) and chronic stress or hypothalamic–pituitary–adrenal dysregulation (variable ratios). It is a niche marker in functional endocrinology and is not part of routine clinical algorithms.
Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.
2 tests on BiomarkersLabs.com include this biomarker.
Urinary Free Cortisol-to-Cortisone Ratio reference range in this test: Laboratory-specific; typically 0.5–2.0.
Urinary Free Cortisol-to-Cortisone Ratio reference range in this test: Typically 0.4–1.0, time-dependent.
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