What is the reference range for THF + allo-THF to THE Ratio?

The standard reference range for THF + allo-THF to THE Ratio is Laboratory-specific; typically 0.7–1.5.. Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

Which tests measure THF + allo-THF to THE Ratio?

THF + allo-THF to THE Ratio is measured in 1 test on BiomarkersLabs.com, including Adrenal Corticoids Profile.

Biomarker Reference · (THF+allo-THF)/THE

What does the THF + allo-THF to THE Ratio test measure?

THF + allo-THF to THE Ratio ((THF+allo-THF)/THE) is a clinical biomarker used in adrenal-stress assessment. This ratio estimates the relative activity of 11β-hydroxysteroid dehydrogenase enzymes by comparing the sum of cortisol metabolites (THF and allo-THF) to the cortisone metabolite (THE). It is measured in 1 laboratory test on BiomarkersLabs.com.

Reference Range: Laboratory-specific; typically 0.7–1.5.
Units: ratio
Measured In: 1 test
Category: Adrenal

Functional medicine optimalMid-range values; clinical significance of deviations outside the functional-medicine literature is limited.

What is THF + allo-THF to THE Ratio?

This ratio estimates the relative activity of 11β-hydroxysteroid dehydrogenase enzymes by comparing the sum of cortisol metabolites (THF and allo-THF) to the cortisone metabolite (THE). A high ratio suggests deficient cortisol-to-cortisone conversion, while a low ratio indicates enhanced inactivation.

Why is THF + allo-THF to THE Ratio measured?

The ratio is used in specialised endocrine investigation of apparent mineralocorticoid excess, polycystic ovary syndrome, and metabolic syndrome. It is a research and functional-medicine tool rather than a mainstream diagnostic marker.

Reference ranges

Standard reference: Laboratory-specific; typically 0.7–1.5.
Functional medicine optimal: Mid-range values; clinical significance of deviations outside the functional-medicine literature is limited.
Units: ratio

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure THF + allo-THF to THE Ratio

1 test on BiomarkersLabs.com include this biomarker.

BML-ADR-020Comprehensive

Adrenal Corticoids Profile

THF + allo-THF to THE Ratio reference range in this test: Laboratory-specific; typically 0.7–1.5.

Related clinical conditions

Related Biomarkers

Frequently measured alongside

Free CortisolF1 test CortisoneE3 tests TetrahydrocortisolTHF1 test Allotetrahydrocortisolallo-THF1 test TetrahydrocortisoneTHE1 test Urinary Free Cortisol-to-Cortisone RatioF/E2 tests

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