What is the reference range for Tetrahydrocortisol?

The standard reference range for Tetrahydrocortisol is Laboratory-specific; typically 1000–3000 µg/24 h.. Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

Which tests measure Tetrahydrocortisol?

Tetrahydrocortisol is measured in 1 test on BiomarkersLabs.com, including Adrenal Corticoids Profile.

Biomarker Reference · THF

What does the Tetrahydrocortisol test measure?

Tetrahydrocortisol (THF) is a clinical biomarker used in adrenal-stress assessment. Tetrahydrocortisol is a major hepatic metabolite of cortisol, formed by 5α-reductase and 3α-hydroxysteroid dehydrogenase. It is measured in 1 laboratory test on BiomarkersLabs.com.

Reference Range: Laboratory-specific; typically 1000–3000 µg/24 h.
Units: µg/24 h, nmol/24 h
Measured In: 1 test
Category: Adrenal

Functional medicine optimalDetermined by laboratory reference populations; functional interpretation is not standardised.

What is Tetrahydrocortisol?

Tetrahydrocortisol is a major hepatic metabolite of cortisol, formed by 5α-reductase and 3α-hydroxysteroid dehydrogenase. It is excreted in urine conjugated as a glucuronide and represents a substantial fraction of daily cortisol metabolism, integrating both hepatic enzyme activity and total glucocorticoid turnover.

Why is Tetrahydrocortisol measured?

THF is a component of steroid metabolite profiling used to investigate disorders of cortisol production and metabolism. Elevated THF can be seen in Cushing syndrome, while low values may accompany adrenal insufficiency. The ratio of THF to other metabolites helps characterise the activity of hepatic reductase enzymes.

Reference ranges

Standard reference: Laboratory-specific; typically 1000–3000 µg/24 h.
Functional medicine optimal: Determined by laboratory reference populations; functional interpretation is not standardised.
Units: µg/24 h, nmol/24 h

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure Tetrahydrocortisol

1 test on BiomarkersLabs.com include this biomarker.

BML-ADR-020Comprehensive

Adrenal Corticoids Profile

Tetrahydrocortisol reference range in this test: Laboratory-specific; typically 1000–3000 µg/24 h.

Related clinical conditions

Related Biomarkers

Frequently measured alongside

Free CortisolF1 test CortisoneE3 tests Allotetrahydrocortisolallo-THF1 test TetrahydrocortisoneTHE1 test Urinary Free Cortisol-to-Cortisone RatioF/E2 tests THF + allo-THF to THE Ratio(THF+allo-THF)/THE1 test

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