What is the reference range for Tetrahydrocortisone?

The standard reference range for Tetrahydrocortisone is Laboratory-specific; often 1500–4000 µg/24 h.. Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

Which tests measure Tetrahydrocortisone?

Tetrahydrocortisone is measured in 1 test on BiomarkersLabs.com, including Adrenal Corticoids Profile.

Biomarker Reference · THE

What does the Tetrahydrocortisone test measure?

Tetrahydrocortisone (THE) is a clinical biomarker used in adrenal-stress assessment. Tetrahydrocortisone is a hepatic metabolite of cortisone, formed by the same 5α/5β-reductase and 3α-HSD pathway as THF. It is measured in 1 laboratory test on BiomarkersLabs.com.

Reference Range: Laboratory-specific; often 1500–4000 µg/24 h.
Units: µg/24 h, nmol/24 h
Measured In: 1 test
Category: Adrenal

Functional medicine optimalLaboratory reference intervals; functional thresholds not established.

What is Tetrahydrocortisone?

Tetrahydrocortisone is a hepatic metabolite of cortisone, formed by the same 5α/5β-reductase and 3α-HSD pathway as THF. It is the single largest urinary steroid metabolite and reflects both cortisol secretion and its peripheral inactivation to cortisone. THE excretion is a surrogate for total glucocorticoid metabolism.

Why is Tetrahydrocortisone measured?

THE is a major component of 24-hour urinary steroid profiling. Elevated THE is characteristic of Cushing syndrome, while low values accompany adrenal insufficiency. The ratio of THF plus allo-THF to THE is used to estimate 11β-HSD enzyme balance and to screen for rare syndromes of apparent mineralocorticoid excess.

Reference ranges

Standard reference: Laboratory-specific; often 1500–4000 µg/24 h.
Functional medicine optimal: Laboratory reference intervals; functional thresholds not established.
Units: µg/24 h, nmol/24 h

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure Tetrahydrocortisone

1 test on BiomarkersLabs.com include this biomarker.

BML-ADR-020Comprehensive

Adrenal Corticoids Profile

Tetrahydrocortisone reference range in this test: Laboratory-specific; often 1500–4000 µg/24 h.

Related clinical conditions

Related Biomarkers

Frequently measured alongside

Free CortisolF1 test CortisoneE3 tests TetrahydrocortisolTHF1 test Allotetrahydrocortisolallo-THF1 test Urinary Free Cortisol-to-Cortisone RatioF/E2 tests THF + allo-THF to THE Ratio(THF+allo-THF)/THE1 test

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