What does the Gliotoxin, Urine test measure?

Why is Gliotoxin, Urine measured?

Urinary gliotoxin is the most clinically specific mycotoxin in the MycoTOX panel — its detection suggests active Aspergillus fumigatus colonisation of the respiratory tract, invasive aspergillosis in immunocompromised individuals, or sinopulmonary Aspergillus exposure producing urinary gliotoxin metabolite excretion. In functional medicine contexts, urinary gliotoxin is assessed in patients with chronic sinusitis, chronic cough, unexplained immune suppression, or post-mould-exposure illness syndromes where Aspergillus colonisation is a plausible contributor. Elevated urinary gliotoxin in an immunocompromised patient — transplant recipient, haematological malignancy, HIV — warrants urgent infectious disease evaluation for invasive aspergillosis, which is a life-threatening condition. In immunocompetent patients, elevated urinary gliotoxin more likely reflects colonisation or repeated airway exposure than invasive disease. # REVIEWER FLAG: Urinary gliotoxin as a diagnostic marker for invasive aspergillosis or Aspergillus colonisation has limited mainstream evidence base — reviewer to assess whether clinical framing requires additional caveating regarding diagnostic sensitivity and specificity.

Reference ranges

Standard reference

# REVIEWER FLAG: Confirm Mosaic Diagnostics reference range for urinary gliotoxin — gliotoxin is an Aspergillus fumigatus-specific mycotoxin; its presence in urine is specifically associated with invasive or colonising Aspergillus fumigatus infection rather than dietary exposure. Confirm whether Mosaic Diagnostics has established a validated population reference range for urinary gliotoxin and what their clinical positivity threshold is.

Functional medicine optimal

Undetectable or below the Mosaic Diagnostics detection threshold (most appropriate interpretive target for this virulence factor mycotoxin). # REVIEWER FLAG: Confirm Mosaic Diagnostics' detection limit and whether they designate a 'detectable but below clinical concern' tier.

Units

ppb (µg/L), ng/g creatinine

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.