What does the Zearalenone and Metabolites, Urine test measure?

Why is Zearalenone and Metabolites, Urine measured?

Elevated urinary zearalenone and metabolites reflect recent dietary exposure from contaminated cereal grains and processed grain products. In functional and integrative medicine, zearalenone is assessed as a xenoestrogen contributor to oestrogen dominance patterns, precocious puberty in girls, subfertility, menstrual irregularity, and reproductive endocrine disruption — clinical concerns arising from its oestrogen receptor agonist activity even at low dietary exposure levels. Male exposure is associated with feminising effects including gynaecomastia and reduced sperm quality at higher exposure concentrations. Exposure source identification — contaminated grain, corn, and processed foods — and dietary modification are the primary clinical interventions. # REVIEWER FLAG: The clinical evidence base for zearalenone as a clinically significant xenoestrogen at levels encountered in Western dietary exposure (as opposed to livestock-level contamination) is debated — reviewer to confirm appropriate interpretive framing.

Reference ranges

Standard reference

# REVIEWER FLAG: Confirm Mosaic Diagnostics reference range for urinary zearalenone and metabolites — confirm whether zearalenone, alpha-zearalanol (α-ZAL), and beta-zearalanol (β-ZAL) are measured as discrete metabolites or as a combined value.

Functional medicine optimal

# REVIEWER FLAG: Confirm Mosaic Diagnostics' interpretive zones for urinary zearalenone.

Units

ppb (µg/L), ng/g creatinine

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.